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Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of CAE 2021, Volume 23, Issue 1,   Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: #231f20">drug research and development, innovation of traditional Chinese medicine, clinical practice of drugsof integrative pharmacy and proposes future development strategies for integrative pharmacy.drugs should be innovated, a drug evaluation system that adapts to integrative pharmacy should be developed,and a new drug development system should be established for integrative drugs.drugs should be emphasized.

Keywords： integrative pharmacy     integrative drugs     new drug development     drug evaluation     clinical medication guidance    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providefocuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 152-159 doi: 10.1007/s11684-017-0499-6

Abstract: construct a new medical system that is more suitable for human health and disease treatment, holistic integrative

Keywords： holistic integrative medicine     precision medicine     general practice     medicine    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen     root system architecture     phytohormone     crosstalk     nitrogen-use efficiency     breeding strategy    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugsfor Chinese BCL patients on the basis of the current application status of oral drugs in China, combinedThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Employing electricity-consumption monitoring systems and integrative time-series analysis models: A case

Seiya MAKI, Shuichi ASHINA, Minoru FUJII, Tsuyoshi FUJITA, Norio YABE, Kenji UCHIDA, Gito GINTING, Rizaldi BOER, Remi CHANDRAN

Frontiers in Energy 2018, Volume 12, Issue 3,   Pages 426-439 doi: 10.1007/s11708-018-0560-4

Abstract:

The Paris Agreement calls for maintaining a global temperature less than 2°C above the pre-industrial level and pursuing efforts to limit the temperature increase even further to 1.5°C. To realize this objective and promote a low-carbon society, and because energy production and use is the largest source of global greenhouse-gas (GHG) emissions, it is important to efficiently manage energy demand and supply systems. This, in turn, requires theoretical and practical research and innovation in smart energy monitoring technologies, the identification of appropriate methods for detailed time-series analysis, and the application of these technologies at urban and national scales. Further, because developing countries contribute increasing shares of domestic energy consumption, it is important to consider the application of such innovations in these areas. Motivated by the mandates set out in global agreements on climate change and low-carbon societies, this paper focuses on the development of a smart energy monitoring system (SEMS) and its deployment in households and public and commercial sectors in Bogor, Indonesia. An electricity demand prediction model is developed for each device using the Auto-Regression eXogenous model. The real-time SEMS data and time-series clustering to explore similarities in electricity consumption patterns between monitored units, such as residential, public, and commercial buildings, in Bogor is, then, used. These clusters are evaluated using peak demand and Ramadan term characteristics. The resulting energy-prediction models can be used for low-carbon planning.

Keywords： electricity monitoring     electricity demand prediction     multiple-variable time-series modeling     time-series cluster analysis     Indonesia    

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Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 411-417 doi: 10.1007/s11684-013-0293-z

Abstract: telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugsThese results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres

Keywords： telomere     antineoplasic drugs     conventional chemotherapies    

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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1501-8

Abstract:

• Oxidation of methotrexate by high-valent metal-oxo species was first explored.

Keywords： Anticancer drugs     High-valent metal-oxo species     Oxidation kinetics     Reaction mechanisms     Multi-endpoint    

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Stroke prevention: an update

Marie-Germaine Bousser

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 22-34 doi: 10.1007/s11684-012-0178-6

Abstract: modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugsreduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs

Keywords： stroke     prevention     vascular risk factors     cerebral infarction     cerebral hemorrhage     anti-thrombotic drugs    

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Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Strategic Study of CAE 2021, Volume 23, Issue 2,   Pages 169-174 doi: 10.15302/J-SSCAE-2021.02.016

Abstract: The Chinese and western integrative medicine, a unique medical model in China, has played an importantdraw experience from the fight against the epidemic to promote the development of Chinese and western integrativeFirst, we review the achievements of the Chinese and western integrative medicine since 1949 using literaturereview and questionnaire survey, and summarize the key roles of this integrative medicine in the preventionSubsequently, we analyze the weaknesses of the integrative medicine in terms of medical resources, clinical

Keywords： Chinese and western integrative medicine     evidence-based medicine     evaluation system     talent training    

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Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 374-379 doi: 10.1007/s11684-015-0411-1

Abstract:

This study aimed to determine the relationship between the different factors of analgesic therapy and the compliance of chronic pain inpatients. We prospectively investigated 100 consecutive inpatients with non-cancer chronic pain who were hospitalized to receive oral analgesic treatment in the Pain Department of West China Hospital from May 2013 to October 2013. Patients who completed the treatment plan were recorded as good compliance, whereas patients who partly completed or even refused the treatment were recorded as moderate or non-compliance, respectively. A total of 73 (73.7%), 17 (17.1%), and 9 (9.2%) patients showed good, moderate, and non-compliance, respectively. Univariate analyses showed significantly better compliance among farmers, patients educated in college or above, with family income of<3000 CNY, and with severe or moderate pain than those employed and unemployed (P=0.02), patients educated below college (P=0.013), with family income of≥3000 CNY (P=0.025), and with mild pain (P<0.001), respectively. Logistic regression analysis showed that the family income of≥3000 CNY (OR: 2.50, 95%CI: 1.65–4.51, P=0.021) and mild pain (OR: 1.27, 95%CI: 1.03–3.31, P=0.016) were associated with moderate or non-compliance with oral analgesic treatment. In conclusion, the low compliance with oral treatment of analgesics was found in Chinese inpatients with chronic pain and compliance was negatively associated with family income and degree of pain of patients.

Keywords： chronic pain     inpatient     oral paregoric drugs     compliance    

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Title Author Date Type Operation

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Employing electricity-consumption monitoring systems and integrative time-series analysis models: A case

Seiya MAKI, Shuichi ASHINA, Minoru FUJII, Tsuyoshi FUJITA, Norio YABE, Kenji UCHIDA, Gito GINTING, Rizaldi BOER, Remi CHANDRAN

Journal Article

Telomeric impact of conventional chemotherapy

Yiming Lu, Waiian Leong, Olivier Guérin, Eric Gilson, Jing Ye

Journal Article

A Review of the International Workshop on “Technological Upgradation of Drugs/Pharmaceutical & Agrochemical

LI Zhengming

Journal Article

Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water

Journal Article

Stroke prevention: an update

Marie-Germaine Bousser

Journal Article

Development Strategy of Chinese and Western Integrative Medicine Under New Circumstances

Wang Conghui, Feng Zhe, Yin Zhiwei, Li Shuang, Chen Xiangmei

Journal Article

Factors related to compliance with oral analgesic treatment of inpatients with chronic pain

Hong Zhu,Yuzhu Zheng,Hui Gao,Li Liu,Lie Yang

Journal Article